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KMID : 1094020090260050429
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Journal of Veterinary Clinics
2009 Volume.26 No. 5 p.429 ~ p.432
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Increased Expression of MET and RON Receptor Tyrosine Kinases in Canine Cutaneous Melanotic Tumor
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Han Jae-Ik
Kim Dae-Yong
Na Ki-Jeong
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Abstract
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Aberrant translocation of -catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.
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KEYWORD
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canine melanotic tumor, MET, RON, RTKs, Wnt/-catenin signaling pathway
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